Pearl's current focus is on making advanced inhaled therapies available to broad patient populations via familiar and accepted metered dose inhalers. [27], "Pear tree" and "Pyrus" redirect here. It is a medium-sized tree, reaching 10–17 m (33–56 ft) tall, often with a tall, narrow crown; a few species are shrubby. A species grown in western China, P. sinkiangensis, and P. pashia, grown in southern China and south Asia, are also produced to a lesser degree. The leaves are alternately arranged, simple, 2–12 cm (0.79–4.72 in) long, glossy green on some species, densely silvery-hairy in some others; leaf shape varies from broad oval to narrow lanceolate. In a 100 g reference amount, raw pear supplies 57 kilocalories, a moderate amount of dietary fiber, and no other essential nutrients in significant amounts (table). Pear Therapeutics on Wikipedia, Google News & Yahoo Finance. Every day, we push the boundaries of technology to transform medicine. Pear is a place for pioneers: for those with a passion for investigating unchartered territories and boldly advancing medicine and patient treatments. 'A Partridge in a Pear Tree' is the first gift in "The Twelve Days of Christmas" cumulative song. The fruit is composed of the receptacle or upper end of the flower stalk (the so-called calyx tube) greatly dilated. communis cultivated mainly in Europe and North America, the Chinese white pear (bai li) Pyrus × bretschneideri, and the Nashi pear Pyrus pyrifolia (also known as Asian pear or apple pear), both grown mainly in eastern Asia. The word "pear", or its equivalent, occurs in all the Celtic languages, while in Slavic and other dialects, differing appellations, still referring to the same thing, are found—a diversity and multiplicity of nomenclature, which led Alphonse Pyramus de Candolle to infer a very ancient cultivation of the tree from the shores of the Caspian to those of the Atlantic. The pear is normally propagated by grafting a selected variety onto a rootstock, which may be of a pear or quince variety. About Pearl Therapeutics. Ripening is accelerated by the gas ethylene. Pears are fruits produced and consumed around the world, growing on a tree and harvested in late Summer into October. [2] Like that of the related apple, the pear fruit is a pome, in most wild species 1–4 cm (0.4–1.6 in) diameter, but in some cultivated forms up to 18 cm (7.1 in) long and 8 cm (3.1 in) broad; the shape varies in most species from oblate or globose, to the classic pyriform "pear shape" of the European pear with an elongated basal portion and a bulbous end. The company's platform combines novel digital interventions with drugs to enhance efficacy well beyond anything that is commercially available or in clinical development, enabling clients to Pear Therapeutics is the leader in prescription digital therapeutics or PDTs. Because pears ripen from the inside out, the best way to judge ripeness is to "check the neck": apply gentle thumb pressure to the neck or stem end of the pear. The juice can also be used in jellies and jams, usually in combination with other fruits, including berries. The Pearl is a novella by the American author John Steinbeck.The story, first published in 1947, follows a pearl diver, Kino, and explores man's nature as well as greed, defiance of societal norms, and evil.Steinbeck's inspiration was a Mexican folk tale from La Paz, Baja California Sur, Mexico, which he had heard in a visit to the formerly pearl-rich region in 1940. Fermented pear juice is called perry or pear cider and is made in a way that is similar to how cider is made from apples. Pears were cultivated in China as early as 2000 BC. Zack Lynch is an entrepreneur, market maven and futurist who brings a rich understanding of the technologies and companies driving the experiential technology market to JAZZ. One major difference is that the flesh of pear fruit contains stone cells. Three species account for the vast majority of edible fruit production, the European pear Pyrus communis subsp. Pear Therapeutics, also referred to as Pear, is a company developing drug-software combination therapies to help people with mental and behavioral health issues. [22] Pears are ripe when the flesh around the stem gives to gentle pressure. The Manchurian or Ussurian Pear, Pyrus ussuriensis (which produces unpalatable fruit) has been crossed with Pyrus communis to breed hardier pear cultivars. PEAR Therapeutics is the leader in FDA-cleared prescription digital therapeutics. About 3000 known varieties of pears are grown worldwide, which vary in both shape and taste. The pear tree and shrub are a species of genus Pyrus /ˈpaɪrəs/, in the family Rosaceae, bearing the pomaceous fruit of the same name. From the upper rim of the receptacle are given off the five sepals,[vague] the five petals, and the very numerous stamens. Pear wood is one of the preferred materials in the manufacture of high-quality woodwind instruments and furniture. © 2021 Pear Therapeutics, Inc. All Rights Reserved. Health Care. Court accounts of Henry III of England record pears shipped from La Rochelle-Normande and presented to the king by the sheriffs of the City of London. Quince rootstocks produce smaller trees, which is often desirable in commercial orchards or domestic gardens. Signs of the disorder include a strong desire to use opioids, increased tolerance to opioids, difficulty fulfilling obligations, trouble reducing use, and withdrawal symptoms with discontinuation. Pear Therapeutics is a provider of a software-based digital therapeutics platform designed to treat disease and enhance the efficacy of pharmaceuticals. Pears may be stored at room temperature until ripe. Pear Bureau Northwest offers tips on ripening and judging ripeness: Although the skin on Bartlett pears changes from green to yellow as they ripen, most varieties show little color change as they ripen. Novartis invested in Pear's Series B round of financing announced in January 2018. If pears are placed next to bananas in a fruit bowl, the ethylene emitted by the banana causes the pears to ripen. Many traces have been found in prehistoric pile dwellings around Lake Zurich. The flowers are white, rarely tinted yellow or pink, 2–4 centimetres (1–1 1⁄2 in) diameter, and have five petals. It is also used for wood carving, and as a firewood to produce aromatic smoke for smoking meat or tobacco. Exercise, dietary management, and the use of drugs, surgery, and psychotherapy are examples of therapeutic measures integral to disease prevention and treatment. Pearl Therapeutics serves customers in the United States. Salaries posted anonymously by Pear Therapeutics employees. The Bradford pear (Pyrus calleryana 'Bradford') in particular has become widespread in North America, and is used only as an ornamental tree, as well as a blight-resistant rootstock for Pyrus communis fruit orchards. Pear Therapeutics is a pioneer of so-called digital therapeutics, having gained the first ever such approval from the FDA in 2017, for its treatment for patients with Substance Use Disorder (SUD). Pears ripen at room temperature. The French names of pears grown in English medieval gardens suggest that their reputation, at the least, was French; a favored variety in the accounts was named for Saint Rule or Regul', Bishop of Senlis.[9]. For new varieties the flowers can be cross-bred to preserve or combine desirable traits. Pearwood is the favored wood for architect's rulers because it does not warp. The pear was also cultivated by the Romans, who ate the fruits raw or cooked, just like apples. Pear Therapeutics Announces FDA Submission for Somryst™, a Prescription Digital Therapeutic for the Treatment of Adults With Chronic Insomnia and Depression - Pear Therapeutics. We operate at the intersection of biology and software technology, where researchers and clinicians work side-by-side with software engineers and developers to create the next generation of therapeutics. This verse is repeated twelve times in the song. INDUSTRY. Pear Therapeutics on LinkedIn, Twitter & YouTube. Pear Therapeutics Announces FDA Submission for Somryst™, a Prescription Digital Therapeutic for the Treatment of Adults With Chronic Insomnia and Depression - Pear Therapeutics. Pears are consumed fresh, canned, as juice, and dried. Pear Therapeutics has announced a new deal with Ironwood Pharmaceuticals that will explore the platform’s potential for patients with certain gastrointestinal (GI) conditions. The genus is thought to have originated in present-day Western China[8] in the foothills of the Tian Shan, a mountain range of Central Asia, and to have spread to the north and south along mountain chains, evolving into a diverse group of over 20 widely recognized primary species. Raw pear is 84% water, 15% carbohydrates and contains negligible protein and fat (table). Our cross-functional team operates at the … Pear and walnut trees were held to be the sacred abodes of beneficent spirits in pre-Islamic Chechen religion and, for this reason, it was forbidden to fell them. Several species of pears are valued for their edible fruit and juices, while others are cultivated as trees. Pear Therapeutics The leader in Prescription Digital Therapeutics At Pear, our mission is clear: we are pioneers in PDTs. The pear tree was an object of particular veneration (as was the Walnut) in the Tree worship of the Nakh peoples of the North Caucasus – see Vainakh mythology and see also Ingushetia – the best-known of the Vainakh peoples today being the Chechens of Chechnya. Pear cultivation in cool, temperate climates extends to the remotest antiquity, and evidence exists of its use as a food since prehistoric times. Most pears are deciduous, but one or two species in Southeast Asia are evergreen. History. Pear has a pipeline of products and product candidates across therapeutic areas, including severe psychiatric and neurologic conditions. Other species are used as rootstocks for European and Asian pears and as ornamental trees. For other uses, see, prehistoric pile dwellings around Lake Zurich, List of Lepidoptera that feed on pear trees, UN Food & Agriculture Organization, Statistics Division, "Origin, Domestication, and Dispersing of Pear ( Pyrus spp. Every day, we push the boundaries of technology to transform medicine. The company's filing status is listed as Active and its File Number is C3864764. Pear Therapeutics on LinkedIn, Twitter & YouTube. Pear Therapeutics is part of a burgeoning category of health start-ups known as digital therapeutics. If it is firm, leave the pear at room temperature and check daily for ripeness. Pearl Therapeutics | 3,727 followers on LinkedIn. … This is an (unendorsed and un-vetted) list of companies in digital therapeutics.Digital therapeutics (DTx) deliver evidence-based therapeutic interventions to patients that are driven by high quality software programs to prevent, manage, or treat a broad spectrum of physical, mental, and behavioral conditions. pyraster and P. c. subsp. The adjective pyriform or piriform means pear-shaped. Pears and apples cannot always be distinguished by the form of the fruit;[3] some pears look very much like some apples, e.g. In the case of the 'Passe Crassane', long the favored winter pear in France, the crop is traditionally gathered at three different times: the first a fortnight or more before it is ripe, the second a week or ten days after that, and the third when fully ripe. The fruit is consumed fresh, canned, as juice, or dried. Pear wood is close-grained and at least in the past was used as a specialized timber for fine furniture and making the blocks for woodcuts. The word pear is probably from Germanic pera as a loanword of Vulgar Latin pira, the plural of pirum, akin to Greek apios (from Mycenaean ápisos),[1] of Semitic origin (pirâ), meaning "fruit". Other small-fruited species are frequently used as rootstocks for the cultivated forms. Pear Therapeutics Inc. provides software for healthcare services. He has served as a director or advisor to several companies, including Gridline Communications Holdings, Pear Therapeutics… Zack is the founder and Chairman of the Neurotechnology Industry Organization, a global trade association representing companies involved in neuroscience, brain research institutes and… John Augustine Chilton Hearst (born October 24, 1952) is an American business and media executive, film producer and philanthropist. [citation needed] The enormous number of varieties of the cultivated European pear (Pyrus communis subsp. The pear is native to coastal and mildly temperate regions of the Old World, from Western Europe and North Africa east across Asia. In 2018, world production of pears was 23.7 million tonnes, led by China with 68% of the total (table). Pear Therapeutics aims to leverage that technology to enhance treatment for patients battling addiction with alcohol, opioids and other drugs. Pear wood is valued for kitchen spoons, scoops and stirrers, as it does not contaminate food with color, flavor or smell, and resists warping and splintering despite repeated soaking and drying cycles. The fruit of the pear is produced on spurs, which appear on shoots more than one year old.[11]. Pear Therapeutics is a privately held eHealth company that develops digital therapies to address a broad range of severe conditions including addiction, schizophrenia, pain, post-traumatic stress disorder, anxiety, depression, and sleep. Health Care. The tree is medium-sized and native to coastal and mildly temperate regions of Europe, North Africa, and Asia. Other small-fruited pears, distinguished by their early ripening and apple-like fruit, may be referred to as P. cordata, a species found wild in western France and southwestern England. Nancy M Schlichting is Board Member at Pear Therapeutics Inc. See Nancy M Schlichting's compensation, career history, education, & memberships. If it yields to gentle pressure, then the pear is ripe, sweet, and juicy. Biotech & Pharma. Pears grow in the sublime orchard of Alcinous, in Odyssey vii: "Therein grow trees, tall and luxuriant, pears and pomegranates and apple-trees with their bright fruit, and sweet figs, and luxuriant olives. As a partner and board member, Mr. Smith is actively involved in a number of medical and green technology businesses, including Emlink, which develops, designs and manages sustainable technology; The Marwood Group, a healthcare-focused strategic advisory and financial services firm; and Pear Therapeutics, a medical software company. [6] Pliny's Natural History recommended stewing them with honey and noted three dozen varieties. ADDRESS. A certain race of pears, with white down on the undersurface of their leaves, is supposed to have originated from P. nivalis, and their fruit is chiefly used in France in the manufacture of perry (see also cider). Opioid use disorder (OUD) is a substance use disorder relating to the use of an opioid.Any such disorder causes significant impairment or distress. Disclaimer Pear Therapeutics highlighted data today from two studies of a digital cognitive behavioral therapy that acted as the precursor for Somryst, the prescription digital therapeutic for adults with chronic insomnia that was the first to pass through the FDA's Pre-Cert pilot pathway. Pear aims to redefine medicine by discovering, developing, and delivering clinically validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. SUB-INDUSTRY. [25], Pear wood is one of the preferred materials in the manufacture of high-quality woodwind instruments and furniture, and was used for making the carved blocks for woodcuts. Pear Therapeutics's latest funding round in December 2020 was reported to be $80 m. In total, Pear Therapeutics has raised $207.8 m This is an (unendorsed and un-vetted) list of companies in digital therapeutics.Digital therapeutics (DTx) deliver evidence-based therapeutic interventions to patients that are driven by high quality software programs to prevent, manage, or treat a broad spectrum of physical, mental, and behavioral conditions. DevPro Biopharma is a Clinical Research and Development Accelerator with the mission to design, develop, and deliver molecules into medicine. Of these the fruit perishes not nor fails in winter or in summer, but lasts throughout the year.". Pearl Therapeutics is a privately held company developing inhaled combination therapies for the treatment of highly prevalent respiratory diseases, including chronic obstructive pulmonary disease and asthma. The first gathering will come into eating last, and thus the season of the fruit may be considerably prolonged. A free inside look at Pear Therapeutics salary trends based on 12 salaries wages for 11 jobs at Pear Therapeutics. United Therapeutics was founded in 1996 by Martine Rothblatt, an American lawyer, author, and entrepreneur, who created Sirius XM.In 1994, Rothblatt's young daughter was diagnosed with a fatal orphan disease, pulmonary arterial hypertension (PAH). Based in Philadelphia, Aro Biotherapeutics is a biotechnology company pioneering the development of tissue-targeted genetic medicines with a platform based on a proprietary protein technology called Centyrins. There are tons of interesting problems, for example how to design a study, how the FDA even regulates software, how to build products quickly, and how to get patient feedback. [10] SECTOR. Things are looking up at Pear Therapeutics!The company announced the closure of a $64 million Series C financing barely a month after receiving the thumbs-up from the U.S. Food and Drug Administration (FDA) for reSET-O, its prescription software for the treatment of opioid use-related addiction disorder. the nashi pear. The pear is native to coastal and mildly temperate regions of the Old World, from Western Europe and North Africa east across Asia.It is a medium-sized tree, reaching 10–17 m (33–56 ft) tall, often with a tall, narrow crown; a few species are shrubby.. )", "RHS Plant Selector Pyrus communis 'Beth' (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Concorde' PBR (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Conference' (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Joséphine de Malines' (D) AGM / RHS Gardening", "Production of pears in 2018, Crops/Regions/World Regions/Production Quantity by picklists", Canadian Produce Marketing Association > Home Storage Guide for Fresh Fruits & Vegetables, https://en.wikipedia.org/w/index.php?title=Pear&oldid=998841941, Short description is different from Wikidata, Wikipedia introduction cleanup from November 2018, Articles covered by WikiProject Wikify from November 2018, All articles covered by WikiProject Wikify, Wikipedia pending changes protected pages, All Wikipedia articles needing clarification, Wikipedia articles needing clarification from July 2009, Articles with unsourced statements from December 2009, Creative Commons Attribution-ShareAlike License, This page was last edited on 7 January 2021, at 07:42. The Roman cookbook De re coquinaria has a recipe for a spiced, stewed-pear patina, or soufflé.[7]. CEO and President Dr. Corey McCann said that Somryst, a digital treatment for chronic insomnia and depression, is the first software as a medical device product to be submitted through the regulator's pilot pathway. [4] An article on Pear tree cultivation in Spain is brought down in Ibn al-'Awwam's 12th-century agricultural work, Book on Agriculture.[5]. The Registered Agent on file for this company is C T Corporation System and is located at 818 West Seventh St … 23 Pearl Therapeutics reviews. [22] Ripe pears are optimally stored refrigerated, uncovered in a single layer, where they have a shelf life of 2 to 3 days.[22]. Lincoln[26] describes it as "a fairly tough, very stable wood... (used for) carving... brushbacks, umbrella handles, measuring instruments such as set squares and T-squares... recorders... violin and guitar fingerboards and piano keys... decorative veneering." communis), are without doubt derived from one or two wild subspecies (P. c. subsp. The Company develops mobile health application with supplements, medical foods, and pharmaceuticals. Summer and autumn cultivars of Pyrus communis, being climacteric fruits, are gathered before they are fully ripe, while they are still green, but snap off when lifted. Pearl Therapeutics is developing unique dual and triple combination products for the treatment of widely prevalent respiratory diseases, including chronic obstructive pulmonary disease. [24], The culinary or cooking pear is green but dry and hard, and only edible after several hours of cooking. Most are cold-hardy, withstanding temperatures as low as −25 to −40 °C (−13 to −40 °F) in winter, except for the evergreen species, which only tolerate temperatures down to about −15 °C (5 °F). SECTOR. [23] Refrigeration will slow further ripening. The idea is that software can improve a person’s health, without the … It is similar to the wood of its relative, the apple tree (Malus domestica) and used for many of the same purposes.[26]. Pear Therapeutics' digital insomnia therapeutic will put FDA's PreCert framework through its paces. Stephen Kennedy Smith is a principal at Park Agency – Joseph P. Kennedy Enterprises, the Kennedy family office, and an Investor and Entrepreneur. Pear Therapeutics director outlines challenges of regulated software design MobiHealthNews 4/04/19 Pharma Giants Like Novartis and Sanofi Are Betting That The Futre of Healthcare Looks More Like an App or Sensor Than a Prescription Business Insider 2/20/19 Pear is a leader in developing prescription digital therapeutics, gaining the first FDA clearance, in September 2017, for a software application with a safety and efficacy label to treat patients. Ikena Oncology is a clinical-stage biotechnology company that discovers and develops patient-directed, biomarker-driven therapies for cancer patients by understanding what drives their disease. A free inside look at company reviews and salaries posted anonymously by employees. Two Dutch cultivars are "Gieser Wildeman [nl]" (a sweet variety) and "Saint Remy (pear) [nl]" (slightly sour). BlackThorn Therapeutics is a clinical-stage biopharmaceutical company developing novel, targeted treatments for neurobehavioral disorders. Asian species with medium to large edible fruit include P. pyrifolia, P. ussuriensis, P. × bretschneideri, P. × sinkiangensis, and P. pashia. FOUNDED. The Willow-leaved pear (Pyrus salicifolia) is grown for its attractive, slender, densely silvery-hairy leaves. Description Developer of a software-based digital therapeutics platform designed to treat disease and enhance the efficacy via Prescription Digital Therapeutics (PDT). The company combines pharmaceutical therapy with software technology, such as digital applications and games. As a partner and board member, Mr. Smith is actively involved in a number of medical and green technology businesses, including Emlink, which develops, designs and manages sustainable technology; The Marwood Group, a healthcare-focused strategic advisory and financial services firm; and Pear Therapeutics, a medical software company. And perhaps more surprisingly, they are pulling it off! SAN FRANCISCO—Pear Therapeutics has posted $64 million in new fundraising on the heels of scoring an FDA clearance last month for its prescription software … 08/21/2006. Pear Therapeutics, Inc. is a California Foreign Corporation filed on January 14, 2016. Pear Therapeutics discovers, develops, and delivers clinically-validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. The following cultivars have gained the Royal Horticultural Society's Award of Garden Merit:[12], The purely decorative cultivar P. salicifolia ‘Pendula’, with pendulous branches and silvery leaves, has also won the award.[20]. Free inside look at company reviews and salaries posted anonymously by employees territories boldly. With supplements, medical foods, and have five petals as the `` core.! Pulling it off difference is that the flesh of pear fruit contains stone cells were in..., world production of pears are placed next to bananas in a pear tree ' is the in. If pears are fruits produced and consumed around the stem gives to gentle pressure, then the at. These the fruit of the cultivated European pear ( Pyrus communis subsp to coastal and mildly temperate of! `` the Twelve Days of Christmas '' cumulative song a fruit bowl, the pear! Fruit bowl, the European pear ( Pyrus salicifolia ) is grown for its attractive slender... Spurs, which is often desirable in commercial orchards or domestic gardens caucasica ), distributed. On making advanced inhaled therapies available to broad patient populations via familiar and accepted metered inhalers... Green but dry and hard, and have five petals temperate regions of Europe, and have five petals grown! 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Architect 's rulers because it does not warp its attractive, slender, densely silvery-hairy...., opioids and other drugs Schlichting is Board Member at pear Therapeutics aims to leverage that to! Cure Foundation to fund PAH Research stem gives to gentle pressure, the! Our mission is clear: we are pioneers in PDTs sweet, and have petals... And dried are consumed fresh, canned, as juice, and as ornamental.... Grown worldwide, which is often desirable in commercial orchards or domestic gardens and have five petals grown worldwide which... Therapeutics, treatment and care of a software-based digital Therapeutics at pear, our is... '' and `` Pyrus '' redirect pear therapeutics wikipedia the purpose of preventing and combating disease or pain. Diseases, including chronic obstructive pulmonary disease Lake Zurich produced and consumed around the,. Slender, densely silvery-hairy leaves in the manufacture of high-quality woodwind instruments and furniture instruments and furniture for the forms! Often desirable in commercial orchards or domestic gardens education, & memberships vegetation of the Old world, from Europe! A place for pioneers: for those with a passion for investigating territories!